DHFR
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Dihydrofolate reductase (DHFR) is an enzyme that catalyzes the reduction of dihydrofolate (H2F) to tetrahydrofolate (H4F) utilizing nicotinamide adenine dinucleotide phosphate (NADPH) as the hydride (H-) donor, in which the pro-R hydrogen of NADPH is transferred to C6 of the pteridine ring with concomitant protonation at the N5 position. The functional DHFR gene (approximately 30 kb with six exons and five introns) has been identified to encode DHFR enzyme. Human DHFR enzyme is a monomeric protein of 186 amino acids, which is characterized by containing a highly conserved dinucleotide-binding domain consisting of seven parallel and one antiparallel β-strands intercalated by α-helices.
Products Related to DHFR(7)
- GC10405MethotrexateCAS: 59-05-2Purity: >98.00%
Methotrexate est un antimétabolite antifolate qui inhibe efficacement l'activité de la dihydrofolate réductase (DHFR), sa valeur d'IC50 est approximativement 7nM.
- GC11610PemetrexedCAS: 150399-23-8Purity: >99.00%
Pemetrexed (also known as pemetrexed disodium) is a novel antifolate antimetabolite targeting multiple enzymes involved in both pyrimidine and purine synthesis.
- GC16333Cycloguanil (hydrochloride)CAS: 152-53-4Purity: >99.50%
Le cycloguanil (chlorhydrate), le métabolite actif du Proguanil, agit sur les schizontes du paludisme dans les érythrocytes et les hépatocytes.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC10405 | Methotrexate | 59-05-2 | >98.00% | |
Methotrexate est un antimétabolite antifolate qui inhibe efficacement l'activité de la dihydrofolate réductase (DHFR), sa valeur d'IC50 est approximativement 7nM. | ||||
| GC11610 | Pemetrexed | 150399-23-8 | >99.00% | |
Pemetrexed (also known as pemetrexed disodium) is a novel antifolate antimetabolite targeting multiple enzymes involved in both pyrimidine and purine synthesis. | ||||
| GC12919 | Pralatrexate | 146464-95-1 | >98.00% | |
A dihydrofolate reductase inhibitor | ||||
| GC16333 | Cycloguanil (hydrochloride) | 152-53-4 | >99.50% | |
Le cycloguanil (chlorhydrate), le métabolite actif du Proguanil, agit sur les schizontes du paludisme dans les érythrocytes et les hépatocytes. | ||||
| GC17694 | Pemetrexed disodium hemipenta hydrate | 357166-30-4 | >99.00% | |
| GC17867 | Pyrimethamine | 58-14-0 | >99.50% | |
A dihydrofolate reductase inhibitor | ||||
| GC73335 | DHFR-IN-4 | 2820126-49-4 | >99.00% | |
DHFR-IN-4 est un puissant inhibiteur de la déshydrofolate réductase (dhfr) avec une IC50 de 123 nm. | ||||