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FABP

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Fatty acid-binding proteins (FABPs) are members of the intracellular lipid-binding protein (iLBP) family and are involved in reversibly binding intracellular hydrophobic ligands and trafficking them throughout cellular compartments, including the peroxisomes, mitochondria, endoplasmic reticulum and nucleus. FABPs are small, structurally conserved cytosolic proteins consisting of a water-filled, interior-binding pocket surrounded by ten anti-parallel beta sheets, forming a beta barrel. At the superior surface, two alpha-helices cap the pocket and are thought to regulate binding. FABPs have broad specificity, including the ability to bind long-chain (C16-C20) fatty acids, eicosanoids, bile salts and peroxisome proliferators.

FABPs are ubiquitously expressed throughout tissues that are highly active in FA metabolism and comprise several isoforms. To date, nine FABP protein-coding genes have been identified in the human genome. These include liver (L-FABP), intestine- (I-FABP), heart- (H-FABP), adipocyte- (A-FABP), epidermal- (E-FABP), ileal- (Il-FABP), brain- (B-FABP), myelin- (M-FABP) and testis-FABP (T-FABP).

Products Related to FABP(8)

  • GC11894 structure
    GC11894BMS 309403
    CAS: 300657-03-8
    Purity: >98.00%

    BMS 309403 est un inhibiteur puissant, actif par voie orale et sélectif de la protéine liant les acides gras des adipocytes (FABP4), sa valeur d'IC50 est 0,71μM.

  • GC31356 structure
    GC31356HTS01037
    CAS: 682741-29-3
    Purity: >99.50%

    HTS01037 est un inhibiteur de la liaison des acides gras ; et un antagoniste compétitif des interactions protéine-protéine médiées par AFABP/aP2 avec un Ki de 0,67 μM.

  • GC36432 structure
    GC36432LDN-0088050
    CAS: 353484-30-7
    Purity: >98%
  • GC50283 structure
    GC50283HM 50316
    CAS: 1310361-52-4
    Purity: >98%

    High affinity FABP4 inhibitor

  • GC61783 structure
    GC61783BMS-309403 sodium
    CAS: 2802523-05-1
    Purity: >98.50%

    Le sodium BMS-309403 est un inhibiteur puissant, actif par voie orale et s&eacute;lectif de la prot&eacute;ine de liaison aux acides gras des adipocytes (&eacute;galement connu sous le nom de FABP4, aP2), avec un Kis <2, 250 et 350 nM pour FABP4, FABP3 et FABP5, respectivement.

  • GC65322 structure
    GC65322FABPs ligand 6
    CAS: 2988135-14-2
    Purity: >98.00%

    FABPs ligand 6 est un inhibiteur des prot&eacute;ines FABP5 et FABP7, avec des valeurs de K d de 874nM et 20nM, respectivement.

  • GC79674 structure
    GC79674FABP4/5-IN-6
    CAS: 2975215-64-4
    Purity: >98%

    FABP4/5-IN-6 is an orally active, potent FABP4/5 inhibitor ( Ki = 0.41/2.53 μM), showing low selectivity over FABP3 ( Ki = 59.72 μM).

  • GC79764 structure
    GC79764(E/Z)-ABP/PPAR modulator 1
    Purity: >97.00%

    (E/Z)-ABP/PPAR modulator 1 is a mixture of the E and Z isomers of ABP/PPAR modulator 1.