Foravirumab (CR4098) is a monoclonal antibody against rabies virus glycoprotein antigenic site III.
Foravirumab (CR4098) recognizes epitopes localized in antigenic site III. Foravirumab still binds to the mutated glycoprotein (N336D) expressed on PER.C6 cells. Foravirumab shows similar neutralizing potency and breadth as CR57, and neutralizes CR57 escape mutants[1].
In Syrian hamster bearing natural rabies virus, Foravirumab (CR4098; 10, 20, and 40 IU/kg) provids protection against the lethal natural rabies virus infection[1].
References:
[1]. Alexander B H Bakker, et al. Novel human monoclonal antibody combination effectively neutralizing natural rabies virus variants and individual in vitro escape mutants. J Virol. 2005 Jul;79(14):9062-8.