[Sar1, Ile8]-Angiotensin II (TFA) is a peptide that has multiple effects on vascular smooth muscle, including contraction of normal arteries and hypertrophy or hyperplasia of cultured cells or diseased vessels.
[Sar1, Ile8]-Angiotensin II (TFA) has multiple effects on vascular smooth muscle, including contraction of normal arteries and hypertrophy or hyperplasia of cultured cells or diseased vessels. [Sar1, Ile8]-Angiotensin II (TFA) activates both the NADPH and NADH oxidases, and stimulates superoxide anion formation in vascular smooth muscle cells[1].
[1]. Griendling KK, et al. Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circ Res. 1994 Jun;74(6):1141-8.