CDC25B-IN-1 |
| Catalog No.GC35627 |
Le CDC25B-IN-1 (composé 4a) est un puissant inhibiteur de la phosphatase du cycle de division cellulaire 25B (CDC25B), avec un Ki de 8,5 μM. CDC25B-IN-1 inhibe puissamment la prolifération cellulaire et la formation de colonies, provoque une augmentation de la phase G2/M.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2374831-10-2
Sample solution is provided at 25 µL, 10mM.
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CDC25B-IN-1 (compound 4a) is a potent inhibitor of cell division cycle 25B (CDC25B) phosphatase, with a Ki of 8.5 μM. CDC25B-IN-1 potently inhibits cell proliferation and colony formation, causes an increase of the G2/M phase[1]. Ki: 8.5 μM (CDC25B phosphatase)[1]
[1]. Cerchia C, et al. Discovery of Novel Naphthylphenylketone and Naphthylphenylamine Derivatives as Cell Division Cycle 25B (CDC25B) Phosphatase Inhibitors: Design, Synthesis, Inhibition Mechanism, and in Vitro Efficacy against Melanoma Cell Lines. J Med Chem. 2019 Aug 8;62(15):7089-7110.
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