PF-03654746 |
| Catalog No.GC36878 |
PF-03654746 est un antagoniste puissant et sélectif des récepteurs de l'histamine H3 avec une pénétration cérébrale élevée.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 935840-31-6
Sample solution is provided at 25 µL, 10mM.
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PF-03654746 is a potent and selective histamine H3 receptor antagonist with high brain penetration.PF-03654746 reduces allergen-induced nasal symptoms, might be a novel therapeutic strategy to further explore allergic rhinitis[1].PF-03654746 improves cognitive efficacy and disease-modifying effects in Alzheimer's disease (AD)[2].
[1]. Stokes JR, et al. The effects of an H3 receptor antagonist (PF-03654746) with fexofenadine on reducing allergic rhinitis symptoms. J Allergy Clin Immunol. 2012 Feb;129(2):409-12, 412.e1-2. [2]. Brioni JD, et al. Discovery of histamine H3 antagonists for the treatment of cognitive disorders and Alzheimer's disease. J Pharmacol Exp Ther. 2011 Jan;336(1):38-46.
Average Rating: 5 (Based on Reviews and 3 reference(s) in Google Scholar.)
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