Histone H3 (1-25), amide acetate is a synthetic N-terminal tail peptide derived from histone H3, which can be used to identify substrates of histone methyltransferases (HMTs). Histone H3 (1-25), amide acetate can serve as a parent backbone for the preparation of various modified peptides [1].
In Vitro, Histone H3 (1-25), amide acetate is site-specifically labeled with a 5-FAM fluorophore at the C-terminus for fluorescence polarization interaction assays[1].
References:
[1]. Brandon CJ, et al. BRD4 recruitment into HP1 condensates desilences transcription without erasure of repressive chromatin. Nature cell biology. 2026 Sep;28(9):1846-1856.
In Vitro, Histone H3 (1-25), amide acetate is site-specifically labeled with a 5-FAM fluorophore at the C-terminus for fluorescence polarization interaction assays[1].
References:
[1]. Brandon CJ, et al. BRD4 recruitment into HP1 condensates desilences transcription without erasure of repressive chromatin. Nature cell biology. 2026 Sep;28(9):1846-1856.