IBR2 |
| Catalog No.GC32912 |
IBR2 est un inhibiteur puissant et spécifique de RAD51 et inhibe la réparation des cassures double brin de l'ADN médiée par RAD51. IBR2 perturbe la multimérisation de RAD51, accélère la dégradation de la protéine RAD51 médiée par le protéasome, inhibe la croissance des cellules cancéreuses et induit l'apoptose.
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Cas No.: 313526-24-8
Sample solution is provided at 25 µL, 10mM.
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IBR2 is a specific RAD51 inhibitor.
IBR2 shows interesting RAD51 inhibition activities. RAD51 is rapidly degraded in IBR2-treated cancer cells, and the homologous recombination repair is impaired, subsequently leading to cell death. The IC50 values of the original IBR2 are in the range of 12-20 µM for most tested cancer cell lines. IBR2 can inhibit the growth of triple-negative human breast cancer cell line MBA-MD-468 with an IC50 of 14.8 µM[1].
[1]. Zhu J, et al. Synthesis, molecular modeling, and biological evaluation of novel RAD51 inhibitors. Eur J Med Chem. 2015;96:196-208.
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