JWH 031 is a synthetic cannabinoid (CB) with a relatively low binding affinity for the central CB1 receptor (Ki = 399 nM). Despite its low affinity for CB1, this pyrrole-based cannabinoid is efficacious in reducing spontaneous activity and increasing antinociception in mice.[1] This product is intended for forensic and research applications.
Reference:
[1]. Wiley, J.L., Compton, D.R., Dai, D., et al. Structure-activity relationships of indole- and pyrrole-derived cannabinoids. J. Pharmacol. Exp. Ther. 285(3), 995-1004 (1998).