L-796778 acetate is a selective agonist of the sst3 receptor. In CHO-K1 cells expressing the hsst3 receptor, L-796778 acetate is a partial agonist that inhibits Forskolin -stimulated cAMP production with an IC50 value of 18 nM. L-796778 acetate has anticonvulsant effect [1].
References:
[1]. Pfeiffer M,et al. Homo- and heterodimerization of somatostatin receptor subtypes. Inactivation of sst(3) receptor function by heterodimerization with sst(2A). J Biol Chem. 2001 Apr 27;276(17):14027-36.
References:
[1]. Pfeiffer M,et al. Homo- and heterodimerization of somatostatin receptor subtypes. Inactivation of sst(3) receptor function by heterodimerization with sst(2A). J Biol Chem. 2001 Apr 27;276(17):14027-36.