L-797591 hydrochloride is a selective sst 1 agonist. L-797591 hydrochloride mimicks the effects of SRIF-14 and SRIF-28 by potently inhibiting either Forskolin -stimulated or CRH-stimulated cAMP accumulation [1].
In Vitro, L-797591 (10-7 M) hydrochloride inhibits Forskolin-stimulated cAMP accumulation in cortical neuron monolayers[1]. L-797591 (1 μM; 1 h) hydrochloride inhibits CRH-stimulated cAMP accumulation in E17-18 cortical neurons[1].
References:
[1]. Blake AD, et al. Somatostatin receptor subtype 1 (sst(1)) regulates intracellular 3',5'-cyclic adenosine monophosphate accumulation in rat embryonic cortical neurons: evidence with L-797,591, an sst(1)-subtype-selective nonpeptidyl agonist. Neuropharmacology. 2001;40(4):590-596.
In Vitro, L-797591 (10-7 M) hydrochloride inhibits Forskolin-stimulated cAMP accumulation in cortical neuron monolayers[1]. L-797591 (1 μM; 1 h) hydrochloride inhibits CRH-stimulated cAMP accumulation in E17-18 cortical neurons[1].
References:
[1]. Blake AD, et al. Somatostatin receptor subtype 1 (sst(1)) regulates intracellular 3',5'-cyclic adenosine monophosphate accumulation in rat embryonic cortical neurons: evidence with L-797,591, an sst(1)-subtype-selective nonpeptidyl agonist. Neuropharmacology. 2001;40(4):590-596.