Λ-Cyhalothrin is a high efficiency, broad-spectrum type II synthetic pyrethroid insecticide containing α-cyano group. Λ-Cyhalothrin is used to control a wide range of pests in a variety of applications. Λ-Cyhalothrin is a neurotoxin that targets sodium channels in the membranes of neurons in the central nervous system[1].
The mechanism of Λ-Cyhalothrin toxicity produces delay in sodium channel inactivation, which leads to persistent depolarization of the nerve membrane. Λ-Cyhalothrin produces membrane depolarization, calcium ion infl ux, and neurotransmitter release from rat brain synaptosomes[1]. Λ-Cyhalothrin possesses estrogenic properties and has an ability to function as a xenoestrogen promoting human breast carcinoma cell proliferation in vitro[1].Λ-Cyhalothrin has found multiple uses in pest (fleas, cockroaches, flies, and ants) control[1].Λ-Cyhalothrin is highly effective against the malaria transmitting species of Anopheles[1].
The effect of Λ-Cyhalothrin (i.p.) on memory, movement activity, and co-ordination in mice exposed to bilateral clamping of the carotid arteries (BCCA) is investigated. Neither memory nor movement co-ordination are impaired by BCCA or Λ-Cyhalothrin. Exploratory locomotor activity is significantly reduced in the BCCA/LCH group. Spontaneous movement activity is significantly reduced in the BCCA/Λ-Cyhalothrin group . Exposure to Λ-Cyhalothrin coexisting with BCCA decreases motor activity in the mice in 2 subsequent 30-min[1].
[1]. Barbara Nieradko-Iwanicka, et al. Effect of Lambda-Cyhalothrin on Memory and Movement in Mice After Transient Incomplete Cerebral Ischemia. Ann Agric Environ Med. 2011;18(1):41-5.