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Leukotriene C4-d5 methyl ester (Synonyms: LTC4d5 methyl ester)

Catalog No.GC47558 Copy One-Click Copy Product Info

A neuropeptide with diverse biological activities

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Leukotriene C4-d5 methyl ester Chemical Structure

Cas No.: 73958-10-8

Taille Prix Stock Qté
25 μg
254,00 $US
En stock
50 μg
484,00 $US
En stock
100 μg
916,00 $US
En stock

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Sample solution is provided at 25 µL, 10mM.



Description of Leukotriene C4-d5 methyl ester

Leukotriene C4-d5 (LTC4-d5) methyl ester contains five deuterium atoms at the 19, 19', 20, 20 and 20 positions. It is intended for use as an internal standard for the quantification of LTC4 methyl ester by GC- or LC-mass spectrometry. LTC4 is the parent cysteinyl-leukotriene produced by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. LTC4 is produced by neutrophils, macrophages, and mast cells, and by transcellular metabolism in platelets.1 It is one of the constituents of slow-reacting substance of anaphylaxis and exhibits potent smooth muscle contracting activity.2 LTC4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute allergic hypersensitivity.3,4 The concentration of LTC4 required to produce marked contractions of lung parenchymal strips and isolated tracheal rings is about 1 nM.4 LTC4 methyl ester is a more lipid soluble form of LTC4. The biological activity of LTC4 methyl ester has not been reported.

1.Maclouf, J.A., and Murphy, R.C.Transcellular metabolism of neutrophil-derived leukotriene A4 by human platelets. A potential cellular source of leukotriene C4J. Biol. Chem.263(1)174-181(1988) 2.Piper, P.J.Formation and actions of leukotrienesPhysiol. Rev.64(2)744-761(1984) 3.Samuelsson, B.Leukotrienes: Mediators of immediate hypersensitivity reactions and inflammationScience220(4597)568-575(1983) 4.Lefer, A.M.Leukotrienes as mediators of ischemia and shockBiochem. Pharmacol.35(2)123-127(1986)

Chemical Properties of Leukotriene C4-d5 methyl ester

Cas No. 73958-10-8 SDF
Synonymes LTC4d5 methyl ester
Canonical SMILES O=C(OC)CCC[C@H](O)[C@H](SCC(C(NCC(O)=O)=O)NC(CCC(N)C(O)=O)=O)/C=C/C=C/C=C\C/C=C\CCCC([2H])([2H])C([2H])([2H])[2H]
Formula C31H44D5N3O9S M.Wt 644.8
Solubility DMF: 50 mg/ml,DMSO: 50 mg/ml,Ethanol: 1 mg/ml,Ethanol:H20 (95:5): 2 mg/ml,PBS (pH 7.2): 0.1 mg/ml Storage Store at -80°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Leukotriene C4-d5 methyl ester

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1 mg 5 mg 10 mg
1 mM 1.5509 mL 7.7543 mL 15.5087 mL
5 mM 310.2 μL 1.5509 mL 3.1017 mL
10 mM 155.1 μL 775.4 μL 1.5509 mL
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In vivo Formulation Calculator (Clear solution) of Leukotriene C4-d5 methyl ester

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 37 reference(s) in Google Scholar.)

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