Cyclooxygenase

The biological effects of prostaglandin D2 (PGD2) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and CRTH2/DP2.

Prostaglandin E2 activates four E prostanoid (EP) receptors, EP1-4.

Celecoxib carboxylic acid acyl-β-D-glucuronide is a phase II metabolite of celecoxib.

Prostacyclin (PGI2) is a cyclooxygenase metabolite with antithrombotic properties found in vascular endothelial cells.

Cholesteryl arachidonate is a cholesterol ester that is found in plasma and the adrenal gland.

Ciprostene is the 9β-methyl analog of carbaprostacyclin and a stable analog of PGI2.

Diclofenac methyl ester is a hydrophobic prodrug form of the non-steroidal anti-inflammatory drug (NSAID) diclofenac.

Corey prostaglandin (PG)-lactone diol is a versatile, chiral intermediate used in the preparation of PGs and PG analogs.

Fluprostenol lactone diol is an intermediate used in the preparation of fluprostenol.

Fluprostenol is an F-series prostaglandin analog which has been approved for many years as a luteolytic in veterinary animals.

Fluprostenol is an F-series prostaglandin analog which has been approved for many years as a luteolytic in veterinary animals.

2-arachidonyl glycerol (2-AG) exhibits cannabinoid (CB) agonist activity at the CB1 receptor, is an important endogenous monoglyceride species, and is thus considered to be the natural ligand for the CB1 receptor.

Four G protein-coupled receptors, EP1-4, initiate cellular signaling in response to prostaglandin PGE2.

I-SAP is a high affinity TP receptor antagonist.

KMN-80, un dérivé de PGE1, est un agoniste sélectif et puissant du récepteur EP4 avec un IC50 et un Ki de 3 nM et 2,35 nM, respectivement.

L-902,688 est un agoniste des récepteurs EP4 puissant, sélectif et actif par voie orale avec un Ki de 0,38 nM et une CE50 de 0,6 nM.

LAS191859 is a potent antagonist of CRTH2/DP2 with IC50 values of 9.58, 14, 15.5, and 7.6 nM for recombinant human, rat, mouse, and guinea pig CRTH2/DP2 receptors, respectively.

Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has been modified to an N-ethyl amide.

Latanoprost is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug.

There are currently four prostaglandin (PG) derivatives which have been approved for human clinical use for the treatment of glaucoma.

Nocloprost is a stable prostaglandin E2 analog with gastroprotective and ulcer-healing properties.

ONO-AE3-208 is an antagonist of the EP4 receptor (Ki = 1.3 nM) that less potently affects EP3, FP, and TP receptors (Kis = 30, 790, and 2,400 nM, respectively) and is without effect on other prostanoid receptors.

PAF C-18 is a naturally occurring phospholipid produced upon stimulation through two distinct pathways known as the "remodeling" and 'de novo' pathways.

Prostaglandin D2 (PGD2) plays a pharmacological role in allergic and asthmatic anaphylaxis, normal physiological sleep and lowering of body temperature, as well as inhibits platelet aggregation and relaxes vascular smooth muscle.