L-902,688 |
| Catalog No.GC44023 |
L-902,688 est un agoniste des récepteurs EP4 puissant, sélectif et actif par voie orale avec un Ki de 0,38 nM et une CE50 de 0,6 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 634193-54-7
Sample solution is provided at 25 µL, 10mM.
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Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a Gs protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis. L-902,688 is a highly potent agonist of the human PGE2 receptor, EP4. It demonstrates a Ki value of 0.38 nM and an EC50 value of 0.6 nM and is >4,000-fold selective for EP4 over other EP and prostanoid receptors. L-902,688 induces thermal hyperalgesia when injected into guinea pig forepaw and increases vasodilation of human pulmonary vein.
Average Rating: 5 (Based on Reviews and 32 reference(s) in Google Scholar.)
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