LP 12 drochloride drate is a potent and selective 5-HT7 receptor agonist with a Ki of 0.13 nM. LP 12 drochloride drate displays selectivity for 5-HT7 over D2, 5-HT1A and 5-HT2A receptors (Ki values are 224 nM, 60.9 nM and >1000 nM, respectively).
LP 12 drochloride drate (0.13 nM; spermatozoa) increases the percentage of peractivated spermatozoa. LP 12 drochloride drate do not affect straight-line velocity (VSL), curvilinear velocity (VCL), average-path velocity (VAP), linearity (LIN), straightness (STR), wobbler coefficient (WOB), amplitude of lateral head displacement (ALH), and beat-cross frequency (BCF)[2].
References:
[1]. Marcello Leopoldo, et al. Structure-activity relationship study on N-(1,2,3,4-tetradronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. J Med Chem. 2007 Aug 23;50(17):4214-21.
[2]. Sugiyama Y, et, al. Effects of 5-droxytryptamine on spermatozoal peractivation and in vitro fertilization in mice. J Reprod Dev. 2019 Dec 18;65(6):541-550.