MeO-Suc-RPY-pNA (hydrochloride) (Synonyms: Methoxy-Succinyl-Arg-Pro-Tyr-pNA, Methoxy-Succinyl-Arg-Pro-Tyr-p-nitroanilide, Serine Protease Chromogenic Substrate, S 2586) |
| Catalog No.GC45682 |
A neuropeptide with diverse biological activities
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: N/A
Sample solution is provided at 25 µL, 10mM.
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MeO-Suc-RPY-pNA is a colorimetric substrate for serine proteases, including trypsin, chymotrypsin, kallikrein-related peptidase 7 (KLK7), and kallikrein-related peptidase 3/prostate-specific antigen.1,2,3 Serine proteases preferentially bind to and cleave the Arg-Pro-Tyr (RPY) peptide sequence to release p-nitroanilide (pNA), which can be quantified by colorimetric detection at 405 nm as a measure of serine protease activity.
|2. de Veer, S.J., Furio, L., Swedberg, J.E., et al. Selective substrates and inhibitors for kallikrein-related peptidase 7 (KLK7) shed light on KLK proteolytic activity in the stratum corneum. J. Invest. Dermatol. 137(2), 430-439 (2017).|3. Clark, M.R., Aliyar, H.A., Lee, C.W., et al. Enzymatic triggered release of an HIV-1 entry inhibitor from prostate specific antigen degradable microparticles. Int. J. Pharm. 413(1-2), 10-18 (2011).
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