Microtubule-IN-13 (Compound FB2) is a microtubule inhibitor. Microtubule-IN-13 interferes with microtubule dynamics, leading to defects in the mitotic spindle and persistent mitotic arrest. Microtubule-IN-13 exhibits potent cytotoxicity against multiple cancer cell lines ( IC50 = 0.3-2.7 μM). Microtubule-IN-13 can be used for cancer research [1].
References:
[1]. Abushaikha G M, et al. Identification and Preliminary Characterization of a Novel Tasquinimod Analog that Unexpectedly Induces Mitotic Arrest by Alteration of Microtubule Dynamics[J]. ACS Medicinal Chemistry Letters, 2025.
References:
[1]. Abushaikha G M, et al. Identification and Preliminary Characterization of a Novel Tasquinimod Analog that Unexpectedly Induces Mitotic Arrest by Alteration of Microtubule Dynamics[J]. ACS Medicinal Chemistry Letters, 2025.