Mitraphylline |
| Catalog No.GC40056 |
La mitraphylline est le principal alcaloÏde oxindolique pentacyclique présent chez Uncaria tomentosa.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 509-80-8
Sample solution is provided at 25 µL, 10mM.
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Mitraphylline is the major pentacyclic oxindolic alkaloid found in U. tomentosa and has anti-inflammatory and antiproliferative properties. It reduces production of nitric oxide (NO), IL-8, IL-6, and TNF-α as well as expression of inducible nitric oxide synthase (iNOS) in LPS-activated human neutrophils. Mitraphylline inhibits the growth of SKN-BE(2) neuroblastoma, GAMG glioblastoma, MHH-ES-1 Ewing's sarcoma, and MT-3 breast cancer cells (IC50s = 12.3, 20, 17.15, and 11.18 μM, respectively). In vivo, mitraphylline (30 mg/kg per day) inhibits LPS-induced release of IL-1α, IL-1β, IL-17, and TNF-α in mouse serum.
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