ML406 |
| Catalog No.GC61074 |
ML406 est une sonde À petite molécule qui montre une activité antituberculeuse via M.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 774589-47-8
Sample solution is provided at 25 µL, 10mM.
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ML406 is a small molecule probe that shows anti-tubercular activity via M.tuberculosis BioA (DAPA synthase) enzyme inhibition with an IC50 of 30 nM. M.tuberculosis BioA is an enzyme involved in biotin biosynthesis in M.tuberculosis[1].
ML406 inhibits WT Mycobacterium tuberculosis (Mtb) (H37Rv) growth inhibition with the IC50 of 3.2 μM. BioA is an enzyme involved in biotin biosynthesis in Mtb that may serve as lead compounds for drug development for tuberculosis (TB)[1].
[1]. Dominick Casalena, et al. Discovery of small molecule probe that shows anti-tubercular activity via MtbbioA (DAPA synthase) enzyme inhibition. January 16, 2015.
Average Rating: 5 (Based on Reviews and 4 reference(s) in Google Scholar.)
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