MLS0315771 |
| Catalog No.GC31369 |
MLS0315771 est un inhibiteur compétitif puissant et biologiquement actif de la phosphomannose isomérase (MPI), avec une IC50 ~1 μM et un Ki de 1,4 μM.
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Cas No.: 727664-91-7
Sample solution is provided at 25 µL, 10mM.
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MLS0315771 is a potent and biologically active competitive phosphomannose isomerase (MPI) inhibitor, with an IC50 ~1 μM and a Ki of 1.4 μM.
MLS0315771 increases mannose flux toward glycosylation.MLS0315771 toxicity at higher concentrations is an off-target effect. MLS0315771 is toxic to the zebrafish embryos above 2 μM. At 8-10 μM, ~50% embryos appeare sick within 20 min, and most of them die by 30-60 min[1].
[1]. Sharma V, et al. Phosphomannose isomerase inhibitors improve N-glycosylation in selected phosphomannomutase-deficient fibroblasts. J Biol Chem. 2011 Nov 11;286(45):39431-8.
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