MPPG TFA, phenylglycine analogue, is a potent and selective metabotropic glutamate receptor ( mGluR ) antagonist with a k D value of 9.2 μM. MPPG TFA antagonizes both L-AP4 - and (1 S,3S)-ACPD-induced depressions of the monosynaptic excitation [1].
In Vitro, MPPG (200 μM; 15 min) TFA antagonizes both L-AP4 - and (1 S,3S)-ACPD-induced depressions of the monosynaptic excitation of neonatal rat motoneurones[1].
References:
[1]. Jane DE, et al. New phenylglycine derivatives with potent and selective antagonist activity at presynaptic glutamate receptors in neonatal rat spinal cord. Neuropharmacology. 1995;34(8):851-856.
In Vitro, MPPG (200 μM; 15 min) TFA antagonizes both L-AP4 - and (1 S,3S)-ACPD-induced depressions of the monosynaptic excitation of neonatal rat motoneurones[1].
References:
[1]. Jane DE, et al. New phenylglycine derivatives with potent and selective antagonist activity at presynaptic glutamate receptors in neonatal rat spinal cord. Neuropharmacology. 1995;34(8):851-856.