Necrocide 1 (compound (S)-38) a potent anticancer agent. Necrocide 1 has antiproliferative activity with an IC50 value of 0.48 and 2 nM for MCF-7 and PC3, respectively.
References:
[1]. Synthesis and Antitumor Effect in Vitro and in Vivo of Substituted 1,3-Didroindole-2-onesJ. Med. Chem., Article ASAPDOI: 10.1021/jm100763jPublication Date (Web): September 16, 2010 [2]. Christensen MK, et, al. Synthesis and antitumor effect in vitro and in vivo of substituted 1,3-didroindole-2-ones. J Med Chem. 2010 Oct 14;53(19):7140-5.