NH2-PEG-NH2 (M.W. 2000) is a PEG derivative terminated with amines at both terminals[1]. NH2-PEG-NH2 was fixed on the titanium surface by electrodeposition to inhibit the adsorption of proteins[2]. NH2-PEG-NH2 has been utilized to fabricate polypiperazine-amide nanofiltration (NF) membrane with high rejection and chlorine resistance[3]. NH2-PEG-NH2 has been widely used as a crosslinking agent to prepare stable bio-functionalized lanthanide-containing nanoparticles, which can withstand the freeze-drying process without aggregation[4].
References:[1] Tanaka Y, Matsuo Y, Saito H, et al. Biofunctionalization of Metal Surface by Immobilization of Poly (Ethylene Glycol) Terminated Amine[J]. Advanced Materials Research, 2007, 26: 765-768.
[2] Tanaka Y, Matsuo Y, Komiya T, et al. Characterization of the spatial immobilization manner of poly (ethylene glycol) to a titanium surface with immersion and electrodeposition and its effects on platelet adhesion[J]. Journal of Biomedical Materials Research Part A: An Official Journal of The Society for Biomaterials, The Japanese Society for Biomaterials, and The Australian Society for Biomaterials and the Korean Society for Biomaterials, 2010, 92(1): 350-358.
[3] Tang Y J, Xu Z L, Xue S M, et al. Improving the chlorine-tolerant ability of polypiperazine-amide nanofiltration membrane by adding NH2-PEG-NH2 in the aqueous phase[J]. Journal of Membrane science, 2017, 538: 9-17.
[4] Que Y, Feng C, Lu G, et al. Polymer-coated ultrastable and biofunctionalizable lanthanide nanoparticles[J]. ACS Applied Materials & Interfaces, 2017, 9(17): 14647-14655.