Penicillin G-d5 is intended for use as an internal standard for the quantification of penicillin G by GC- or LC-MS. Penicillin G is a β-lactam antibiotic that is effective mainly for Gram-positive bacteria.1 It has MIC90 values of 0.03, 1, and 4 µg/ml for penicillin-susceptible, -intermediate, and -resistant strains of S. pneumoniae, respectively, and 16-128 µg/ml for various Bacteroides isolates in a broth dilution assay.2,3 Formulations containing penicillin G have been used for the treatment of bacterial infections and in livestock production.
1.Demain, A.L.Production of beta-lactam antibiotics and its regulationProc. Natl. Sci. Counc. Repub. China B.15(4)251-265(1991) 2.Pankuch, G.A., Lichtenberger, C., Jacobs, M.R., et al.Antipneumococcal activities of RP 59500 (quinupristin-dalfopristin), penicillin G, erythromycin, and sparfloxacin determined by MIC and rapid time-kill methodologiesAntimicrob. Agents Chemother.40(7)1653-1656(1996) 3.Aldridge, K.E., Sanders, C.V., Janney, A., et al.Comparison of the activities of penicillin G and new beta-lactam antibiotics against clinical isolates of Bacteroides speciesAntimicrob. Agents Chemother.26(3)410-413(1984)