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Reactive Oxygen Species

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Reactive oxygen species (ROS), such as superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion.

ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.

Products Related to Reactive Oxygen Species(505)

  • GC72755 structure
    GC72755Tempol-d17,15N
    CAS: 90429-66-6

    Tempol-d17,15N est le deutérium marqué Tempol.

  • GC72791 structure
    GC72791Delmitide acetate
    CAS: 501019-16-5
    Purity: >98.00%

    Delmitide acetate est un décapeptide D - isomère actif par voie orale qui possède une forte activité anti - inflammatoire.

  • GC72858 structure
    GC72858Avenanthramide A
    CAS: 108605-70-5
    Purity: >99.00%

    Avenanthramide A est une ptoalexine que l'on trouve dans l'avoine (Avena sativa L.).

  • GC72888 structure
    GC72888CPS-11
    CAS: 145945-21-7
    Purity: >99.00%

    CPS-11 (n - (droxymetl) Thalidomide), un analogue de la Thalidomide, est un puissant agent anticancéreux.

  • GC72995 structure
    GC72995MnTE-2-PyP chloride
    CAS: 219818-60-7
    Purity: >95.00%

    MnTE-2-PyP chloride est un récupérateur de ROS et un puissant radioprotecteur.

  • GC73031 structure
    GC73031Salpyran dihydrochloride
    Purity: >99.00%

    Salpyran dihydrochloride est un chélateur sélectif Cu(II) avec un potentiel thérapeutique.

  • GC73188 structure
    GC73188SFI003
    CAS: 2361332-90-1
    Purity: >99.00%

    SFI003 est un inhibiteur de SRSF3 qui entraîne l’apoptose des cellules CRC via l’axe SRSF3/DHCR24/ROS et présente de puissants effets antitumoraux à la fois in vitro et in vivo.

  • GC73212 structure
    GC73212TH-6
    CAS: 3031349-25-1
    Purity: >95.00%

    TH-6 est un puissant inhibiteur de HDAC avec des IC50 de 0115, 0135, 0242, 0138 et 2120 µm pour HDAC1, HDAC2, hdac3, hdac6 et hdac8, respectivement.

  • GC73225 structure
    GC73225ROS-generating agent 1
    CAS: 2369030-41-9
    Purity: >99.00%

    ROS-generating agent 1 (composé 2c) modifie covalemment le résidu Sec-498 de TrxR pour générer des ROS.

  • GC73543 structure
    GC73543FC-116
    CAS: 2417298-29-2
    Purity: >98.00%

    FC-116 est un inhibiteur de la Tubuline qui inhibe efficacement la croissance tumorale chez la souris.

  • GC74090 structure
    GC74090Dimethyl fumarate-d2
    CAS: 23057-98-9
    Purity: >99.00%

    Dimethyl fumarate-d2 est le deuterium étiqueté fumarate de Dimetl.

  • GC74256 structure
    GC74256Condurango glycoside A
    CAS: 11051-90-4
    Purity: >95.00%

    Condurango glycoside A est un activateur de p53.

  • GC74270 structure
    GC74270Penduletin
    CAS: 569-80-2
    Purity: >99.00%

    Penduletin est un flavonoïde qui peut être isolé de la cire blanche et des épines.

  • GC74668 structure
    GC746683-Methoxy-9H-Carbazole
    CAS: 18992-85-3
    Purity: >99.00%

    3-Methoxy-9H-Carbazole induction de l'activité de la caspase - 3 et de la production cellulaire d'oxygène vivant.

  • GC81540 structure
    GC81540Brevicidine TFA
    Purity: >97.50%

    Brevicidine TFA is an antimicrobial peptide with selective bactericidal activity against Gram-negative pathogens.

  • GC81541 structure
    GC81541BMAP-27 acetate
    Purity: >98.00%

    BMAP-27 acetate is a cationic amphipathic α-helical antimicrobial peptide with anticancer activity.

  • GC81542 structure
    GC815427-O-Galloyl-D-sedoheptulose
    CAS: 233690-85-2
    Purity: >98%

    7-O-Galloyl-D-sedoheptulose is an orally effective polyphenolic compound.

  • GC81543 structure
    GC81543GPX4-IN-19
    CAS: 3102894-57-2
    Purity: >99.00%

    GPX4-IN-19 is an effective GPX4 inhibitor ( IC 50 = 0.311 μM), covalently binds to the Sec 46 site of GPX4.

  • GC81544 structure
    GC81544Copper ionophore I
    CAS: 101264-90-8
    Purity: >98.00%

    Copper ionophore I is an efficient copper ion carrier.

  • GC81545 structure
    GC81545Ferroptosis inducer-12
    Purity: >96.00%

    Ferroptosis inducer-12 is a potent and selective ferroptosis inducer.

  • GC81546 structure
    GC81546iMQT_020
    CAS: 2463893-46-9
    Purity: >99.00%

    iMQT_020 is a selective allosteric SLC1A5_var inhibitor.

  • GC81547 structure
    GC81547Geranyl isovalerate
    CAS: 109-20-6
    Purity: >96.50%

    Geranyl isovalerate is a chemical component that can be extracted from Argyreia Nervosa.

  • GC81548 structure
    GC81548CIGB-552 TFA
    Purity: >98.00%

    CIGB-552 TFA is a cell-penetrating peptide with anti-tumor properties with the IC 50 of 23 μM in H460 cells.

  • GC81553 structure
    GC81553YRDC-IN-1
    CAS: 3120494-74-5
    Purity: >93.50%

    YRDC-IN-1 is a blood-brain barrier-permeable YRDC inhibitor.