Dehydrogenase

Dehydrogenases, belonging to the class of oxidoreductases which catalyze donor-acceptor reactions to transfer electron molecules from the oxidant to the reluctant, are a diverse group of enzymes that are able to transfer one or more hydrides (H-) from a substrate to an electron acceptor, such as nicotinamide adenine dinucleotide (NAD+), nicotinamide adenine dinucleotide phosphate (NADP+) or Riboflavin, through oxidation and reduction. Three commonly studied dehydrogenase enzymes include alcohol dehydrogenase (ADH) which catalyzes the reduction of acetylaldehyde to ethanol in plant cells, succinate dehydrogenase which oxidizes succinate to fumarate, and lactate dehydrogenase which catalyzes the reversible oxidation of lactate to pyruvate.

Products Related to Dehydrogenase(36)

GC16816 Galloflavin
CAS: 568-80-9
Purity: >98.00%
La galloflavine est un puissant inhibiteur de la lactate déshydrogénase (LDH). Les Kis calculés pour le pyruvate sont de 5,46 μM (LDH-A) et 15,06 μM (LDH-B). La galloflavine entrave la prolifération des cellules cancéreuses en bloquant la glycolyse et la production d'ATP.
GC16860 NCT-502
CAS: 1542213-00-2
Purity: >99.00%
Le NCT-502 est un inhibiteur de la phosphoglycérate déshydrogénase humaine (PHGDH), cytotoxique pour les cellules cancéreuses dépendantes de la PHGDH, et réduit la production de sérine dérivée du glucose, avec une IC50 de 3,7 μM contre la PHGDH.
GC16951 Stiripentol
CAS: 49763-96-4
Purity: >99.50%
Stiripentol (STP) est un agent anticonvulsivant, qui peut inhiber la N-déméthylation du CLB en NCLB médiée par le CYP3A4 (de manière non compétitive) et le CYP2C19 (de manière compétitive) avec Ki de 1,59 ± 0,07 et 0,516 ± 0,065 μM et IC50 de 1,58 et 3,29 μM, respectivement .
GC17107 PluriSIn #1 (NSC 14613)
CAS: 91396-88-2
Purity: >99.50%
A selective inhibitor of stearoyl-CoA desaturase
GC17293 PHGDH-inactive
CAS: 1914971-16-6
Purity: >99.50%
La PHGDH-inactive n'a aucune activité contre la PHGDH et sert de contrÔle négatif de NCT-502 et NCT-503.
GC17467 Gimeracil
CAS: 103766-25-2
Purity: >99.50%
A DYPD inhibitor
GC17914 Fomepizole
CAS: 7554-65-6
Purity: >99.50%
Le fomépizole (4-méthylpyrazole) est un puissant inhibiteur du cytochrome P450 (CYP2E1).
GC25039 AG-120 (racemic)
CAS: 1448346-63-1
Purity: >98%
AG-120 (racemic), the racemic mixture of AG-120, is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1) with potential antineoplastic activity.
GC25389 Ethyl potassium malonate
CAS: 6148-64-7
Purity: >98%
Ethyl potassium malonate (Potassium 3-ethoxy-3-oxopropanoate) is used as a competitive inhibitor of the enzyme succinate dehydrogenase. It acts as a precursor to produce (trimethylsilyl)ethyl malonate, which is utilized to prepare beta-ketoesters by acylation and serves as an intermediate for the preparation of ethyl tert-butyl malonate.
GC50508 PKUMDL WQ 2101
CAS: 304481-72-9
Purity: >98%
Negative allosteric modulator of 3-phosphoglycerate dehydrogenase (PHGDH)
GC50509 PKUMDL WQ 2201
CAS: 592474-91-4
Purity: >98%
Negative allosteric modulator of 3-Phosphoglycerate dehydrogenase (PHGDH)
GC81900 CP61 acetate
Purity: >98.50%
CP61 acetate is a CtBP1 and CtBP2 inhibitor that binds to dimeric CtBP1 and allosterically inhibits NADH binding, disrupting the NADH -dependent dimerization of CtBP1 and CtBP2, inducing aberrant mitosis and micronucleus formation, thereby inhibiting cell proliferation and colony formation.

Category Product List
Catalog No.	Product Name	CAS No.	Purity
GC16816	Galloflavin	568-80-9	>98.00%
GC16816	La galloflavine est un puissant inhibiteur de la lactate déshydrogénase (LDH). Les Kis calculés pour le pyruvate sont de 5,46 μM (LDH-A) et 15,06 μM (LDH-B). La galloflavine entrave la prolifération des cellules cancéreuses en bloquant la glycolyse et la production d'ATP.
GC16860	NCT-502	1542213-00-2	>99.00%
GC16860	Le NCT-502 est un inhibiteur de la phosphoglycérate déshydrogénase humaine (PHGDH), cytotoxique pour les cellules cancéreuses dépendantes de la PHGDH, et réduit la production de sérine dérivée du glucose, avec une IC50 de 3,7 μM contre la PHGDH.
GC16951	Stiripentol	49763-96-4	>99.50%
GC16951	Stiripentol (STP) est un agent anticonvulsivant, qui peut inhiber la N-déméthylation du CLB en NCLB médiée par le CYP3A4 (de manière non compétitive) et le CYP2C19 (de manière compétitive) avec Ki de 1,59 ± 0,07 et 0,516 ± 0,065 μM et IC50 de 1,58 et 3,29 μM, respectivement .
GC17107	PluriSIn #1 (NSC 14613)	91396-88-2	>99.50%
GC17107	A selective inhibitor of stearoyl-CoA desaturase
GC17293	PHGDH-inactive	1914971-16-6	>99.50%
GC17293	La PHGDH-inactive n'a aucune activité contre la PHGDH et sert de contrÔle négatif de NCT-502 et NCT-503.
GC17467	Gimeracil	103766-25-2	>99.50%
GC17467	A DYPD inhibitor
GC17914	Fomepizole	7554-65-6	>99.50%
GC17914	Le fomépizole (4-méthylpyrazole) est un puissant inhibiteur du cytochrome P450 (CYP2E1).
GC25039	AG-120 (racemic)	1448346-63-1	>98%
GC25039	AG-120 (racemic), the racemic mixture of AG-120, is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1) with potential antineoplastic activity.
GC25389	Ethyl potassium malonate	6148-64-7	>98%
GC25389	Ethyl potassium malonate (Potassium 3-ethoxy-3-oxopropanoate) is used as a competitive inhibitor of the enzyme succinate dehydrogenase. It acts as a precursor to produce (trimethylsilyl)ethyl malonate, which is utilized to prepare beta-ketoesters by acylation and serves as an intermediate for the preparation of ethyl tert-butyl malonate.
GC50508	PKUMDL WQ 2101	304481-72-9	>98%
GC50508	Negative allosteric modulator of 3-phosphoglycerate dehydrogenase (PHGDH)
GC50509	PKUMDL WQ 2201	592474-91-4	>98%
GC50509	Negative allosteric modulator of 3-Phosphoglycerate dehydrogenase (PHGDH)
GC81900	CP61 acetate	-	>98.50%
GC81900	CP61 acetate is a CtBP1 and CtBP2 inhibitor that binds to dimeric CtBP1 and allosterically inhibits NADH binding, disrupting the NADH -dependent dimerization of CtBP1 and CtBP2, inducing aberrant mitosis and micronucleus formation, thereby inhibiting cell proliferation and colony formation.