(S)-6-Methylnicotine is a nicotinic acetylcholine receptor ( nAChR ) agonist that exhibits agonistic activity on isolated guinea pig ileum. (S)-6-Methylnicotine produces sensations identical to those of nicotine and has addictive potential. (S)-6-Methylnicotine shows high cytotoxicity against human bronchial epithelial cells and exerts a weak effect on the upregulation of lung cancer-related proteins. (S)-6-Methylnicotine can be used in the research of respiratory system diseases [1] [2].
In Vitro, (S)-6-Methylnicotine is a naturally occurring minor tobacco alkaloid present in additive-free cured leaf tobaccos, smokeless tobaccos, and domestic/foreign/Nigerian cigarettes at an all-sample average level of 0.32 µg per g of tobacco material[1]. (S)-6-Methylnicotine confirms presence in Sweet Spearmint, Blue Razz Ice, and Mango Grapefruit Spree Bar e-liquids, with mass accuracy within 7 ppm of the theoretical [M+H]+ ion value[2].
References:
[1]. Pankow JF, et al. Levels of the nicotine analog 6-methyl nicotine as a naturally formed tobacco alkaloid in tobacco and tobacco products. Scientific reports. 2025 May 23;15(1):17945.
[2]. Jordt SE, et al. An electronic cigarette pod system delivering 6-methyl nicotine, a synthetic nicotine analog, marketed in the United States as "PMTA exempt". medRxiv [Preprint]. 2023 Nov 22:2023.11.21.23298778.
In Vitro, (S)-6-Methylnicotine is a naturally occurring minor tobacco alkaloid present in additive-free cured leaf tobaccos, smokeless tobaccos, and domestic/foreign/Nigerian cigarettes at an all-sample average level of 0.32 µg per g of tobacco material[1]. (S)-6-Methylnicotine confirms presence in Sweet Spearmint, Blue Razz Ice, and Mango Grapefruit Spree Bar e-liquids, with mass accuracy within 7 ppm of the theoretical [M+H]+ ion value[2].
References:
[1]. Pankow JF, et al. Levels of the nicotine analog 6-methyl nicotine as a naturally formed tobacco alkaloid in tobacco and tobacco products. Scientific reports. 2025 May 23;15(1):17945.
[2]. Jordt SE, et al. An electronic cigarette pod system delivering 6-methyl nicotine, a synthetic nicotine analog, marketed in the United States as "PMTA exempt". medRxiv [Preprint]. 2023 Nov 22:2023.11.21.23298778.