Scrambled 10Panx TFA (FSVYWAQADR TFA) is an inactive scrambled control peptide of the Pannexin-1 hemichannel inhibitory peptide 10panx [1] [2].
In Vivo, Animal Model: CD1 (adult male, 6-8 weeks, chronic constriction injury model)[2] Dosage: 100 μM, 6 μl Administration: intrasciatic injection; single dose Result: Did not alter CCI-induced mechanical or thermal hyperalgesia. Left mechanical and thermal pain thresholds at reduced levels seen in vehicle-treated CCI mice. Showed no significant improvement across days 1, 2, 3, 4, and 6 post-injection.
In Vitro, Scrambled 10Panx TFA serves as a control peptide, which can be used to determine whether other experimental conditions or peptides exert effects through specific molecular mechanisms[1].
References:
[1]. Thompson RJ, et al. Activation of pannexin-1 hemichannels augments aberrant bursting in the hippocampus. Science (New York, N.Y.). 2008 Dec 05;322(5907):1555-9.
[2]. Wang Q, et al. Inhibition of Schwann cell pannexin 1 attenuates neuropathic pain through the suppression of inflammatory responses. Journal of neuroinflammation. 2022 Oct 04;19(1):244.
In Vivo, Animal Model: CD1 (adult male, 6-8 weeks, chronic constriction injury model)[2] Dosage: 100 μM, 6 μl Administration: intrasciatic injection; single dose Result: Did not alter CCI-induced mechanical or thermal hyperalgesia. Left mechanical and thermal pain thresholds at reduced levels seen in vehicle-treated CCI mice. Showed no significant improvement across days 1, 2, 3, 4, and 6 post-injection.
In Vitro, Scrambled 10Panx TFA serves as a control peptide, which can be used to determine whether other experimental conditions or peptides exert effects through specific molecular mechanisms[1].
References:
[1]. Thompson RJ, et al. Activation of pannexin-1 hemichannels augments aberrant bursting in the hippocampus. Science (New York, N.Y.). 2008 Dec 05;322(5907):1555-9.
[2]. Wang Q, et al. Inhibition of Schwann cell pannexin 1 attenuates neuropathic pain through the suppression of inflammatory responses. Journal of neuroinflammation. 2022 Oct 04;19(1):244.