SM1-71 -R is a reversible analog o SM1-71. SM1-71 -R lacks the acrylamide warhead and therefore cannot form a covalent bond with the kinase. SM1-71 -R can be used as a control compound for SM1-71 [1].
In Vitro, SM1-71-R (1 μM; 2 h) results in inhibition of phosphorylation of p-AKTS473 in H23-KRASG12C cells[1].
References:
[1]. Rao S, et al. A multitargeted probe-based strategy to identify signaling vulnerabilities in cancers. J Biol Chem. 2019 May 24;294(21):8664-8673.
In Vitro, SM1-71-R (1 μM; 2 h) results in inhibition of phosphorylation of p-AKTS473 in H23-KRASG12C cells[1].
References:
[1]. Rao S, et al. A multitargeted probe-based strategy to identify signaling vulnerabilities in cancers. J Biol Chem. 2019 May 24;294(21):8664-8673.