Copeptin (human) |
Catalog No.GA21279
One-Click Copy Product Info
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Copeptin is a peptide composed of 39-amino acids that is produced primarily in paraventricular neurons and the supraoptic nucleus of the hypothalamus.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 78362-34-2
Sample solution is provided at 25 µL, 10mM.
Copeptin is a peptide composed of 39-amino acids that is produced primarily in paraventricular neurons and the supraoptic nucleus of the hypothalamus[1].
Copeptin may aid in the folding of vasopressin during transport. Vasopressin has a direct antidiuretic effect on the kidneys and also causes constriction of peripheral blood vessels. Copeptin can be used as a vasopressin surrogate in clinical test[2-4].
In vivo£¬In In the analysis of systemic anaphylaxis, the body temperature of the model group (Compound 48/80) was significantly lower than that of the control group. Compound 48/80 induced increased serum concentrations of HIS, TNF-¦Á and IL-8[8]. Compound 48/80-induced MC degranulation produced anticonvulsive effects against PTZ-induced epileptic seizures by extending the onset time of both myoclonic-jerk and generalized tonic¨Cclonic seizure, and by shortening the duration of generalized tonic¨Cclonic seizure[9].
References:
[1]. Baranowska B, Kochanowski J. Copeptin - a new diagnostic and prognostic biomarker in neurological and cardiovascular diseases. Neuro Endocrinol Lett. 2019 Dec;40(5):207-214. PMID: 32112544.
[2]. Balanescu S, Kopp P, Gaskill MB, Morgenthaler NG, Schindler C, Rutishauser J. Correlation of plasma copeptin and vasopressin concentrations in hypo-, iso-, and hyperosmolar States. J Clin Endocrinol Metab. 2011 Apr;96(4):1046-52. doi: 10.1210/jc.2010-2499. Epub 2011 Feb 2. PMID: 21289257.
[3]. Morgenthaler NG, Struck J, Alonso C, Bergmann A. Assay for the measurement of copeptin, a stable peptide derived from the precursor of vasopressin. Clin Chem. 2006 Jan;52(1):112-9. doi: 10.1373/clinchem.2005.060038. Epub 2005 Nov 3. PMID: 16269513.
[4]. Christ-Crain M. Vasopressin and Copeptin in health and disease. Rev Endocr Metab Disord. 2019 Sep;20(3):283-294. doi: 10.1007/s11154-019-09509-9. PMID: 31656992.
| Cas No. | 78362-34-2 | SDF | |
| Formula | C177H279N49O58 | M.Wt | 4021.46 |
| Solubility | Soluble in DMSO | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 248.7 μL | 1.2433 mL | 2.4867 mL |
| 5 mM | 49.7 μL | 248.7 μL | 497.3 μL |
| 10 mM | 24.9 μL | 124.3 μL | 248.7 μL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 7 reference(s) in Google Scholar.)