H-His-Tyr-OH is a small dipeptide composed of histidine and tyrosine. H-His-Tyr-OH, a neurolysin activator, exhibited an A50 value of 85.5μM against neurolysin. The half-lives of H-His-Tyr-OH in mouse plasma and brain homogenate are 34.1min and 1.03min, respectively[1]. As a dipeptide component of the dialysate, H‑His‑Tyr‑OH releases amino acids at a more gradual rate and reduces the peak amino acid levels in the blood in a rat peritoneal dialysis model[2]. H‑His‑Tyr‑OH also exhibits antioxidant activity against oxidative damage. H‑His‑Tyr‑OH (2–20mM; 6h) dose‑dependently protected against 200μM 4-hydroxy-trans-nonenal (HNE)‑induced senescence‑associated damage in keratinocytes, as evidenced by restored cellular morphology and improved cell viability[3].
References:
[1] Rahman MS, Kumari S, Esfahani SH, et al. Discovery of First-in-Class Peptidomimetic Neurolysin Activators Possessing Enhanced Brain Penetration and Stability. J Med Chem. 2021;64(17):12705-12722.
[2] Weryński A, et al. Comparison of Kinetic Characteristics of Amino Acid-Based and Dipeptide-Based Peritoneal Dialysis Solutions. Int J Artif Organs. 2006;29(7):681-690.
[3] https://patentimages.storage.googleapis.com/5c/d0/a6/8f0fc660f71a50/WO2004089354A2.pdf.