Z-His-OBzl is a derivative of histidine (His) and can mediate the coordination of Mn2+ co-assembly to form peptide-based photosensitive nanomedicines[1]. Z-His-OBzl acts as the template amino acid derivative to induce near-infrared (NIR) cyanine dye indocyanine green (ICG) co-assembly due to the amphiphilic and positively charged nature [2]. Z-His-OBzl regulates the self-assembly of phthalocyanine tetrasulfonic acid (Pc) into nanoparticles without vesicle structures, exhibiting fluorescence quenching in solution [3]. Z-His-OBzl can be combined with the endogenous biological pigment biliverdin (BV) to prepare nanoparticles with wide near-infrared absorption, which act as photoacoustic imaging (PAI) contrast agents for diagnosing tumors with high spatial resolution and penetration depth[4].
References:
[1] Li S, van Hest J C M, Xing R, et al. Peptide self-assembly meets photodynamic therapy: from molecular design to antitumor applications[J]. Chemical Communications, 2025, 61(73): 13841-13851.
[2] Li S, Chang R, Zhao L, et al. Two-photon nanoprobes based on bioorganic nanoarchitectonics with a photo-oxidation enhanced emission mechanism[J]. Nature Communications, 2023, 14(1): 5227.
[3] Han J, Liu K, Chang R, et al. Photooxidase‐mimicking nanovesicles with superior photocatalytic activity and stability based on amphiphilic amino acid and phthalocyanine co‐assembly[J]. Angewandte Chemie, 2019, 131(7): 2022-2026.
[4] Chang R, Zhao L, Xing R, et al. Functional chromopeptide nanoarchitectonics: molecular design, self-assembly and biological applications[J]. Chemical Society Reviews, 2023, 52(8): 2688-271