Z-His-OBzl |
Catalog No.GA23835
One-Click Copy Product Info
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Z-His-OBzl is a derivative of histidine (His) and can mediate the coordination of Mn2+ co-assembly to form peptide-based photosensitive nanomedicines.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 20794-07-4
Sample solution is provided at 25 µL, 10mM.
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Z-His-OBzl is a derivative of histidine (His) and can mediate the coordination of Mn2+ co-assembly to form peptide-based photosensitive nanomedicines[1]. Z-His-OBzl acts as the template amino acid derivative to induce near-infrared (NIR) cyanine dye indocyanine green (ICG) co-assembly due to the amphiphilic and positively charged nature [2]. Z-His-OBzl regulates the self-assembly of phthalocyanine tetrasulfonic acid (Pc) into nanoparticles without vesicle structures, exhibiting fluorescence quenching in solution [3]. Z-His-OBzl can be combined with the endogenous biological pigment biliverdin (BV) to prepare nanoparticles with wide near-infrared absorption, which act as photoacoustic imaging (PAI) contrast agents for diagnosing tumors with high spatial resolution and penetration depth[4].
References:
[1] Li S, van Hest J C M, Xing R, et al. Peptide self-assembly meets photodynamic therapy: from molecular design to antitumor applications[J]. Chemical Communications, 2025, 61(73): 13841-13851.
[2] Li S, Chang R, Zhao L, et al. Two-photon nanoprobes based on bioorganic nanoarchitectonics with a photo-oxidation enhanced emission mechanism[J]. Nature Communications, 2023, 14(1): 5227.
[3] Han J, Liu K, Chang R, et al. Photooxidase‐mimicking nanovesicles with superior photocatalytic activity and stability based on amphiphilic amino acid and phthalocyanine co‐assembly[J]. Angewandte Chemie, 2019, 131(7): 2022-2026.
[4] Chang R, Zhao L, Xing R, et al. Functional chromopeptide nanoarchitectonics: molecular design, self-assembly and biological applications[J]. Chemical Society Reviews, 2023, 52(8): 2688-271
| Cas No. | 20794-07-4 | SDF | |
| Formula | C21H21N3O4 | M.Wt | 379.42 |
| Solubility | Soluble in DMSO | Storage | Store at -20°C, protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.6356 mL | 13.178 mL | 26.356 mL |
| 5 mM | 527.1 μL | 2.6356 mL | 5.2712 mL |
| 10 mM | 263.6 μL | 1.3178 mL | 2.6356 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 35 reference(s) in Google Scholar.)