GLPBio

Phytic acid sodium salt

Catalog No.: GC18440
COASDSData Sheet
Phytic acid sodium salt is an antinutrient found naturally in legume seeds.

Products are for research use only. Not for human use. We do not sell to patients.

Phytic acid sodium salt
Cas No.: 14306-25-3
25gIn Stock
$20.00
1
100gIn Stock
$35.00
1
250gIn Stock
$66.00
1
500gIn Stock
$107.00
1
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Description

Phytic acid sodium salt is an antinutrient found naturally in legume seeds [1]. Phytic acid sodium salt and its degradation products can scavenge free radicals and reduce oxidative stress [2]. Phytic acid sodium salt chelation of metal ions (such as iron) can reduce metal-catalyzed oxidative reactions [3]. Phytic acid sodium salt exhibits anticancer and antioxidant properties [4].

In MC65 cells, Cell survival rate was significantly improved after Phytic acid sodium salt (100μM; 4d) treatment [5]. In HepG2 cells, Phytic acid sodium salt (0.1-4mM; 24-48h) treatment inhibited cell growth [6].

In dextran sulfate sodium (DSS)-induced UC mice model, Phytic acid sodium salt (0.25g/kg; ig; 14d) treatment improved weight loss, shortened colon length, improved clinical scores, and reduced the release of proinflammatory factors (Il-1β, Il-6, and TNF-α) [7]. In a high-fat diet mice model, Phytic acid sodium salt (0.25-2mg/mL; po; 13 weeks) significantly inhibited obesity and alleviated hepatic steatosis [8].

References:
[1]. Oatway L, Vasanthan T, Helm J H. Phytic acid sodium salt[J]. Food Reviews International, 2001, 17(4): 419-431.
[2]. Graf E, Empson K L, Eaton J W. Phytic acid sodium salt. A natural antioxidant[J]. Journal of Biological Chemistry, 1987, 262(24): 11647-11650.
[3]. Lee B J, Hendricks D G. Metal‐catalyzed oxidation of ascorbate, deoxyribose and linoleic acid as affected by Phytic acid sodium salt in a model system[J]. Journal of Food Science, 1997, 62(5): 935-984.
[4]. Bloot A P M, Kalschne D L, Amaral J A S, et al. A review of Phytic acid sodium salt sources, obtention, and applications[J]. Food Reviews International, 2023, 39(1): 73-92.
[5]. Anekonda T S, Wadsworth T L, Sabin R, et al. Phytic acid sodium salt as a potential treatment for Alzheimer's pathology: evidence from animal and in vitro models[J]. Journal of Alzheimer’s disease, 2011, 23(1): 21-35.
[6]. Al-Fatlawi A A, Al-Fatlawi A A, Irshad M, et al. Rice bran Phytic acid sodium salt induced apoptosis through regulation of Bcl-2/Bax and p53 genes in HepG2 human hepatocellular carcinoma cells[J]. Asian Pacific Journal of Cancer Prevention, 2014, 15(8): 3731-3736.
[7]. Hou X, Sang Y, Dong L. The improved effect and its mechanism of Phytic acid sodium salt on DSS-induced UC mice[J]. Life sciences, 2022, 311: 121139.
[8]. Ran X, Hu G, He F, et al. Phytic acid sodium salt improves hepatic steatosis, inflammation, and oxidative stress in high-fat diet (HFD)-fed mice by modulating the gut–liver axis[J]. Journal of Agricultural and Food Chemistry, 2022, 70(36): 11401-11411.

Protocol

Cell experiment [1]:

Cell lines

MC65 cells

Preparation Method

Cell viability was determined using an MTS assay and a calcium ion assay. At 90% confluence, cells were harvested from TC flasks using 0.05% trypsin/EDTA, washed twice with PBS, and seeded at 15 × 103 cells/well in 96-well plates in OPTIMem medium containing (Tet+) or (Tet-) tetracycline (1μg/mL) and excipients, or Phytic acid sodium salt (100μM). Cells grown under Tet- conditions typically died after approximately 3–4 days of culture, accompanied by expression of endogenous A oligomers, whereas cells grown under Tet+ conditions remained viable during this period. Wells containing growth medium without cells served as background controls, and wells containing vehicle served as positive controls. Each treatment was replicated in 3–6 wells, and the treatment duration for each experiment was 72 hours. Absorbance was measured at a wavelength of 490nm using a Spectra Max PLUS microplate reader. The cell viability under different treatments was determined relative to the cell viability under Tet + treatment. The experiments were repeated at least three times.

Reaction Conditions

100μM; 4d

Applications

Cell survival rate was significantly improved after Phytic acid sodium salt treatment.
Animal experiment [2]:

Animal models

Dextran sulfate sodium (DSS)-induced UC mice model

Preparation Method

The C57BL/6 mice were randomly divided into four groups of five mice each. The specific groups were as follows: no treatment group (NT group), Phytic acid sodium salt feeding group (Phytic acid sodium salt group), DSS modeling group (DSS group), and Phytic acid sodium salt treatment group (Phytic acid sodium salt + DSS group). The mice in the Phytic acid sodium salt and Phytic acid sodium salt + DSS groups were gavaged with Phytic acid sodium salt (0.25g/kg/day) for 21days. After receiving Phytic acid sodium salt for 14days, mice in the DSS and Phytic acid sodium salt + DSS groups were given 2.5% DSS aqueous solution for 7days to develop the mouse model of UC. The body weights of all mice were recorded from day 1 of the DSS feeding. Following the completion of the DSS induction period, all mice were euthanized, and colon samples were collected for subsequent studies.

Dosage form

0.25g/kg; ig; 14d

Applications

Phytic acid sodium salt treatment improved weight loss, shortened colon length, improved clinical scores, and reduced the release of proinflammatory factors (Il-1β, Il-6, and TNF-α).

References:
[1]. Anekonda T S, Wadsworth T L, Sabin R, et al. Phytic acid sodium salt as a potential treatment for Alzheimer's pathology: evidence from animal and in vitro models[J]. Journal of Alzheimer’s disease, 2011, 23(1): 21-35.
[2]. Hou X, Sang Y, Dong L. The improved effect and its mechanism of Phytic acid sodium salt on DSS-induced UC mice[J]. Life sciences, 2022, 311: 121139.

Product Documents

Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
14306-25-3
Molecular Formula
C6H18O24P6·xNa+·yH2O
Molecular Weight
660.04
Solubility
250mg/mL in Water (ultrasonic and warming and heat to 40°C)
Storage
Store at RT
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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