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(S)-Mapracorat Catalog No.GC35002

Size Price Stock Qty
10mM*1mL in DMSO
$663.00
In stock
5mg
$603.00
In stock
10mg
$881.00
In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 887375-15-7 SDF Download SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES CC(C)(C1=C(OCC2)C2=CC(F)=C1)C[C@](O)(CNC3=C4C=CC(C)=NC4=CC=C3)C(F)(F)F
Formula C25H26F4N2O2 M.Wt 462.48
Solubility DMSO: ≥ 50.6 mg/mL (109.41 mM) Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

(S)-Mapracorat is a selective and less active glucocorticoid receptor agonist.

(S)-Mapracorat concentration dependently inhibited TNFα secretion from activated canine PBMC with IC50 value of approximately 0.2 nM.

Intradermal injection of compound 48/80 (50 μg in 50 μL saline) resulted in a clear wheal and flare reaction over the 60 min observation period. Topical pre-treatment with (S)-Mapracorat (0.1%) leads to significant reduction in the wheal and flare responses compared to vehicle (acetone) treated areas.

[1]. BÄumer W , et al. The selective glucocorticoid receptor agonist mapracorat displays a favourable safety-efficacy ratio for the topical treatment of inflammatory skin diseases in dogs. Vet Dermatol. 2017 Feb; 28(1):46-e11.