Amtolmetin guacil (100 μM; 0-60 min) converts to TMT (Tolmetin) along with MED5 (1-methyl-5-p-methylbenzoyl-pyrrol-2-acetamido aceticacid) in rat fresh plasma and rat liver microsomal, rapidly converts to MED5 and MED5 methyl ester without yielding TMT in human fresh plasma and human liver microsomes[3].
| Animal Model: | Male Wistar rats[3] | ||||||||||||||
| Dosage: | 50 mg/kg | ||||||||||||||
| Administration: | p.o.; single dosage | ||||||||||||||
| Result: | Pharmacokinetic Parameters of Amtolmetin guacil in male Wistar rats[3].
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[1]. Marcolongo, R., et al. A Meta-Analysis of the Tolerability of Amtolmetin Guacil, a Novel, Effective Nonsteroidal Anti-Inflammatory Drug, Compared with Established Agents. Clin. Drug Investig. 17, 89-96 (1999).
[2]. Niccoli L, et al. Renal tolerability of three commonly employed non-steroidal anti-inflammatory drugs in elderly patients with osteoarthritis. Clin Exp Rheumatol. 2002 Mar-Apr;20(2):201-7.
[3]. Hotha KK, et al. Species difference in the in vitro and in vivo metabolism of amtolmetin guacil. Arzneimittelforschung. 2010;60(11):667-74.
Product Documents
Chemical Properties
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion
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