Lithium aluminum deuteride |
Catalog No.GD15777
One-Click Copy Product Info
|
Lithium aluminum deuteride is a material applied in isotype labeling, deuterium exchange reactions, deuterium isotope effects, and as a substrate for chemical synthesis (including organometallic compounds). Lithium aluminum deuteride (LiAlD₄) is also widely used as a strong deuteride reducing agent for introducing deuterium into organic molecules.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 14128-54-2
Sample solution is provided at 25 µL, 10mM.
_1-3.$$$39978408@51.jpg');)
_1-9.$$$38538795@65.jpg');)
_1-9.$$$39112701@51.jpg');)
_1-7.$$$37316672@70.jpg');)
_366-372.$$$36198801@70.jpg');)
.$$$38565142@65.jpg');)
_1867-1883.$$$33248023@67.jpg');)
_eads6055.$$$39977546@45.jpg');)
_eadm9805.$$$40080571@45.jpg');)
_eadj3020.$$$39666821@45.jpg');)
_1-20.$$$39757301@28.jpg');)
_1-24.$$$38898113@28.jpg');)
_273-287.$$$36806353@46.jpg');)
_1-16.$$$37156877@44.jpg');)
_1-19.$$$37460805@44.jpg');)
_1291-1307.$$$34518654@46.jpg');)
Lithium aluminum deuteride is a material applied in isotype labeling, deuterium exchange reactions, deuterium isotope effects, substrate for chemical synthesis (including organometallic compounds).
In isotype labeling, lithium aluminum deuteride(1.0M THF solution; 4.0mL; 4.0mmol) reduce [13C15N]benzo[b]thiophene-3-carbonitrile to give [13CD215N]benzo[b]thiophen-3-yl-methylamine stable isotope-labeled compound with four stable isotope atoms[1]. Lithium aluminum deuteride is also used for novel cage oxaheterocycles synthesis (155mg, 4.08mmol in dry THF (20mL)) and deuterium-labeled analogs of the lipid hydroperoxide-derived bifunctional electrophile 4-oxo-2(*E*)-nonenal synthesis as a deuteride donor[2,3]. The role of lithium aluminum deuteride in the selective deuteration of carbonyl-containing molecules aids in elucidating reaction mechanisms and metabolic pathways.
References:
[1] Lin, Ronghui et al. “Expeditious syntheses of stable and radioactive isotope-labeled anticonvulsant agent, JNJ-26990990, and its metabolites.” *Journal of labelled compounds & radiopharmaceuticals* vol. 56,1 (2013): 22-6. doi:10.1002/jlcr.3013
[2] Marchand, A P et al. “Synthesis of novel cage oxaheterocycles.” *The Journal of organic chemistry*vol. 66,6 (2001): 2072-7. doi:10.1021/jo001611c
[3] Arora, Jasbir S et al. “Synthesis of deuterium-labeled analogs of the lipid hydroperoxide-derived bifunctional electrophile 4-oxo-2(*E*)-nonenal.” *Journal of labelled compounds & radiopharmaceuticals* vol. 54,5 (2011): 247-251. doi:10.1002/jlcr.1860
Protocol for [ 13CD2 15N]-C-Benzo[b]thiophen-3-yl-methylamine 6 Synthesis[1]:
1. Add lithium aluminum deuteride (1.0M THF solution; 4.0mL; 4.0mmol) in anhydrous diethyl ether (10mL), [13C15N]benzo[b]thiophene-3-carbonitrile (322.4mg, 2.0 mmol) in anhydrous diethyl ether (6mL) at room temperature dropwise.
2. Stir and heat the reaction mixture in an oil bath to reflux for 3h and then cool into an ice-water bath and quenched by addition of a pH=7.0 buffer solution (20mL).
3. Separate the organic layer and extract the aqueous layer three times with dichloromethane.
4. Combine the organic layers and dry over MgSO4, filter, and evaporate the solvents on a rotary evaporator to give an oil residue.
5. Dissolve the oil residue in a small amount of dichloromethane and subject to chromatography on Biotage Horizon system with silica gel column eluted with 10% methanol in dichloromethane containing about 1% of ammonium hydroxide.
6. Collect and combine fractions containing product, and remove the solvents on a rotary evaporator to give the desired compound as yellowish oil (185.5mg, 55%).
*This protocol only provides a guideline for lithium aluminum deuteride, and should be modified according to your specific needs
References:
[1]Lin, Ronghui et al. “Expeditious syntheses of stable and radioactive isotope-labeled anticonvulsant agent, JNJ-26990990, and its metabolites.” Journal of labelled compounds & radiopharmaceuticals vol. 56,1 (2013): 22-6. doi:10.1002/jlcr.3013
| Cas No. | 14128-54-2 | SDF | |
| Formula | LiAlD4 | M.Wt | 41.98 |
| Solubility | Storage | Store at 2-8°C,protect from light | |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 23.8209 mL | 119.1043 mL | 238.2087 mL |
| 5 mM | 4.7642 mL | 23.8209 mL | 47.6417 mL |
| 10 mM | 2.3821 mL | 11.9104 mL | 23.8209 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)