Lactoferrin (from bovine milk) |
Catalog No.GD15819
One-Click Copy Product Info
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Lactoferrin is a substance released by neutrophils.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 936541-36-5
Sample solution is provided at 25 µL, 10mM.
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Lactoferrin is a substance released by neutrophils. Lactoferrin is an orally active multifunctional iron binding glycoprotein. Lactoferrin prevents cell adhesion, growth and spreading of cell colonies. Lactoferrin also has antiviral activity and inhibits microbial and viral adhesion and entry into host cells. Besides, Lactoferrin has anti-inflammatory, immunomodulatory, and anti-cancer activities.
Lactoferrin (0-1 000 渭g/mL, 7 days) inhibits epithelial cell (HaCaT) growth in a dose-dependent manner[1].
Lactoferrin (500 渭g/mL, 12 days) inhibits the spreading and growth of HaCaT cell colonies[1].
Lactoferrin (1.41 渭M and 0.12 渭M for human and bovine Lactoferrins) inhibits HSV-1 infection in vero cells by 50%[4].
Lactoferrin (recombinant human lactoferrin) (1,000 mg/kg, oral gavage, twice daily for 8 days) inhibits the growth of squamous cell carcinoma (O12) tumors in T cell鈥搃mmunocompromised nu/nu mice by 80%[5].
Lactoferrin (Bovine lactoferrin) (100 and 200 mg/kg, oral gavage,for 30 consecutive days) shows protective effects in a rat model of sepsis-induced acute lung injury[6].
[1]. P枚ll盲nen MT, et al. Lactoferrin impedes epithelial cell adhesion in vitro. J Periodontal Res. 1998 Jan;33(1):8-16.
[2]. Berlutti F, et al. Antiviral properties of lactoferrin--a natural immunity molecule. Molecules. 2011 Aug 16;16(8):6992-7018.
[3]. Cutone A, et al. Lactoferrin's Anti-Cancer Properties: Safety, Selectivity, and Wide Range of Action. Biomolecules. 2020 Mar 15;10(3):456.
[4]. Marchetti M, et al. Lactoferrin inhibits herpes simplex virus type 1 adsorption to Vero cells. Antiviral Res. 1996 Mar;29(2-3):221-31.
[5]. Varadhachary A, et al. Oral lactoferrin inhibits growth of established tumors and potentiates conventional chemotherapy. Int J Cancer. 2004 Sep 1;111(3):398-403.
[6]. Han N, et al. Effect of bovine lactoferrin as a novel therapeutic agent in a rat model of sepsis-induced acute lung injury. AMB Express. 2019 Oct 31;9(1):177.
| Cas No. | 936541-36-5 | SDF | |
| Formula | M.Wt | ~80kDa | |
| Solubility | H2O : ≥ 50 mg/mL | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)