Pectin |
Catalog No.GD19567
One-Click Copy Product Info
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Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 9000-69-5
Sample solution is provided at 25 µL, 10mM.
Pectin is a heteropolysaccharide, derived from the cell wall of higher plants. Pectin involves in the formation of nanoparticles as a delivery vehicle of agents. Pectin is also an adsorbent, a broad-spectrum antimicrobial agent that binds to bacteria toxins and other irritants in the intestinal mucosa, relieves irritated mucosa.
Pectin (5 mg/mL; 24, 48, and 72 h) shows low cytotoxicity on HepG2 cells, and can be made into nanoparticles (PPN), encapsulating Paclitaxel , decreases the Paclitaxel cytotoxicity (%) from 55.6% to 21.7% at 72 h[1].
Pectin (3, 6 mg/mL; 48 h) inhibits Staphylococcus aureus ATCC 25923 growth, with a minimum inhibitory concentration (MIC) of 40 mg/mL[2].
Pectin inhibits Gram-negative Helicobacter pylori, a common human pathogen, shows highest antibacterial activity at pH 5.0, with a minimum inhibitory concentration (MIC) of 0.162 mg/mL and minimum bactericidal concentration (MBC) of 0.325 mg/mL[2].
Pectin displays lower antibacterial activity against E. coli with MICs of 25 mg/mL and 50 mg/mL and MBC values ranging between 25-50 mg/mL[2].
Pectin exhibits the antibacterial activity via its undissociated acid form[2].
Pectin serves as the nanoparticles encapsulating Paclitaxel , (20 mg/kg; i.v.; single dose) significantly delays plasma clearance with detection of Paclitaxel possible up to 48 h in Balb/c mice[1].
[1]. Verma AK, et al. Pharmacokinetics and biodistribution of negatively charged pectin nanoparticles encapsulating paclitaxel. Cancer Nanotechnol. 2013;4(4-5):99-102.
[2]. Ciriminna R, et al. Pectin: A Long-Neglected Broad-Spectrum Antibacterial. ChemMedChem. 2020 Dec 3;15(23):2228-2235.
[3]. Wikiera A, et al. Prozdrowotne w艂a艣ciwo艣ci pektyn [Health-promoting properties of pectin]. Postepy Hig Med Dosw (Online). 2014 Jan 2;68:590-6. Polish.
| Cas No. | 9000-69-5 | SDF | |
| Formula | C5H10O5 | M.Wt | 150.13 |
| Solubility | Storage | 2-8°C away from moisture | |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 6.6609 mL | 33.3045 mL | 66.6089 mL |
| 5 mM | 1.3322 mL | 6.6609 mL | 13.3218 mL |
| 10 mM | 666.1 μL | 3.3304 mL | 6.6609 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)