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Poly(ethylene glycol) bis(carboxymethyl) ether

Catalog No.GD19842 Copy One-Click Copy Product Info

HOOC-PEG-COOH (MW 2000) has two active carboxyl groups at both ends, which can selectively react with the amino groups in peptide coupling agents.

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Poly(ethylene glycol) bis(carboxymethyl) ether Chemical Structure

Cas No.: 39927-08-7

Size Price Stock Qty
5ml
$28.00
In stock
25ml
$115.00
In stock
50ml
$185.00
In stock

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Sample solution is provided at 25 µL, 10mM.



Description of Poly(ethylene glycol) bis(carboxymethyl) ether

HOOC-PEG-COOH (MW 2000) has two active carboxyl groups at both ends, which can selectively react with the amino groups in peptide coupling agents. HOOC-PEG-COOH (MW 2000) is a good cross-linking agent for PEGylation of proteins and peptides, nanoparticles and surface modification[1].

References:
[1].Bian Y, et al. Carboxyl PEGylation of magnetic nanoparticles as antithrombotic and thrombolytic agents by calcium binding. J Colloid Interface Sci. 2023 May 15;638:672-685.

Chemical Properties of Poly(ethylene glycol) bis(carboxymethyl) ether

Cas No. 39927-08-7 SDF
Formula M.Wt 2000 (Average)
Solubility Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Poly(ethylene glycol) bis(carboxymethyl) ether

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1 mg 5 mg 10 mg
1 mM 500 μL 2.5 mL 5 mL
5 mM 100 μL 500 μL 1 mL
10 mM 50 μL 250 μL 500 μL
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**When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / CoA (available online).

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In vivo Formulation Calculator (Clear solution) of Poly(ethylene glycol) bis(carboxymethyl) ether

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

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