Antitrypanosomal agent 9 (compound 1) is a potent antitrypanosomal agent. Antitrypanosomal agent 9 shows inhibitory activity against T. b. brucei, with an IC50 of 1.15 渭M. Antitrypanosomal agent 9 can be used for human African trypanosomiasis (HAT) research.
Antitrypanosomal agent 9 (compound 1) shows inhibitory activity against T. b. rhodesiense, T. cruzi, L. donovani, and P. falciparum, with IC50 values of 0.985 卤 0.076, 107 卤 34.5, 35.7 卤 6.22, and 22.3 卤 1.06 渭M, respectively[1].
Antitrypanosomal agent 9 shows cytotoxicity in L6 cells, with an IC50 of 186 卤 94.2 渭M[1].
[1]. Manos-Turvey Alexandra, et al. Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents. Med Chem Commun. 2015, 6(3), 403鈥?06.
















