GLPBio

Thonningianin B

Catalog No.: GF01060Purity:>98.00%
COASDSData Sheet

Products are for research use only. Not for human use. We do not sell to patients.

Thonningianin B
Cas No.: 271579-12-5
5mgIn Stock
$167.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

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Description

Thonningianin B is an antioxidant and an autophagy enhancer.

Thonningianin B shows strong scavenging action against the DPPH radical. The DPPH radical is scavenged completely by a 34.5 碌M solution of Thonningianin B. In a separate experiment, an IC50 value of Thonningianin B is determined to be 21 渭M[1].
Thonningianin B (0-100 渭M; 24 h) inhibits BV-2 cell viability with an IC50 of 46.74 渭M[2].
Thonningianin B (10 渭M; 24 h) significantly improves the ratio of LC3-II/LC3-I and the average number of GFP-LC3 puncta per cell in BV-2 cells[2].

[1]. Ohtani II, et al. Thonningianins A and B, new antioxidants from the African medicinal herb Thonningia sanguinea. J Nat Prod. 2000 May;63(5):676-9. 

[2]. Zhou XG, et al. Targeting microglial autophagic degradation of the NLRP3 inflammasome for identification of thonningianin A in Alzheimer's disease. Inflamm Regen. 2022 Aug 3;42(1):25. 

Product Documents

Purity:>98.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
271579-12-5
Molecular Formula
C35H30O17
Molecular Weight
722.61
Solubility
DMSO : 66.67 mg/mL (92.26 mM; Need ultrasonic); Methanol : 62.5 mg/mL (86.49 mM; Need ultrasonic)
Storage
2-8°C， sealed storage，away from moisture
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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