Thonningianin B |
Catalog No.GF01060
One-Click Copy Product Info
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Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 271579-12-5
Sample solution is provided at 25 µL, 10mM.
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Thonningianin B shows strong scavenging action against the DPPH radical. The DPPH radical is scavenged completely by a 34.5 碌M solution of Thonningianin B. In a separate experiment, an IC50 value of Thonningianin B is determined to be 21 渭M[1].
Thonningianin B (0-100 渭M; 24 h) inhibits BV-2 cell viability with an IC50 of 46.74 渭M[2].
Thonningianin B (10 渭M; 24 h) significantly improves the ratio of LC3-II/LC3-I and the average number of GFP-LC3 puncta per cell in BV-2 cells[2].
[1]. Ohtani II, et al. Thonningianins A and B, new antioxidants from the African medicinal herb Thonningia sanguinea. J Nat Prod. 2000 May;63(5):676-9.
[2]. Zhou XG, et al. Targeting microglial autophagic degradation of the NLRP3 inflammasome for identification of thonningianin A in Alzheimer's disease. Inflamm Regen. 2022 Aug 3;42(1):25.
| Cas No. | 271579-12-5 | SDF | |
| Formula | C35H30O17 | M.Wt | 722.61 |
| Solubility | DMSO : 66.67 mg/mL (92.26 mM; Need ultrasonic); Methanol : 62.5 mg/mL (86.49 mM; Need ultrasonic) | Storage | 2-8°C， sealed storage，away from moisture |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.3839 mL | 6.9194 mL | 13.8387 mL |
| 5 mM | 276.8 μL | 1.3839 mL | 2.7677 mL |
| 10 mM | 138.4 μL | 691.9 μL | 1.3839 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)