Methyl kakuol shows agonistic activity against TRPA1 with an EC50 of 0.27 碌M.
The maximum concentration (Cmax) of Methyl kakuol at a dose of 2 g/kg (containing 1156 碌g/kg, 294 碌g/kg, 452 碌g/kg, 852 碌g/kg asarinin, sesamin, methyl kakuol, and amide A, respectively) is 98.2 ng/mL[1].
[1]. Takashi Matsumoto, et al. In Vivo Pharmacokinetic Analysis Utilizing Non-Targeted and Targeted Mass Spectrometry and In Vitro Assay against Transient Receptor Potential Channels of Maobushisaishinto and Its Constituent Asiasari Radix. Molecules. 2020 Sep