LASV inhibitor 3.3 is a Lassa fever virus (LASV) inhibitor. LASV inhibitor 3.3 binds with LASV glycoprotein (GP) and promotes virus membrane fusion and infection. LASV inhibitor 3.3 can be used for LASV infection research.
LASV inhibitor 3.3 (1 nM-100 渭M; 1 h) inhibits transduction by murine leukemia virus (MLV) pseudotyped with the indicated viral glycoproteins with an IC50 value of 1.8 渭M[1].
LASV inhibitor 3.3 (1 and 10 渭M; 1 h) inhibits LAMP1 binding to LASV GP in vitro[1].
[1]. Wang MK, et al. Critical role for cholesterol in Lassa fever virus entry identified by a novel small molecule inhibitor targeting the viral receptor LAMP1. PLoS Pathog. 2018 Sep 28;14(9):e1007322.
















