FSCPX

FSCPX irreversibly blocks the binding of [³H]-8-cyclopentyl-1,3dipropylxanthine ([³H]DPCPX), with an IC₅₀ of 11.8卤3.2 nM in DDT₁ MF2 cells^[1].
FSCPX (20 渭M; 48 h) attenuates protection from necrosis and apoptosis in A1AR-overexpressing LLC-PK1 cells^[3].
FSCPX (2-20 渭M; 48 h) reverses the upregulation of HSP27 mRNA and protein in A1AR-overexpressing LLC-PK1 cells without an effect on the mRNA or protein for HSP70^[3].

[1]. Beauglehole AR, et, al. New irreversible adenosine A(1) antagonists based on FSCPX. Bioorg Med Chem Lett. 2002 Nov 4; 12(21): 3179-82. 

[2]. Erdei T, et, al. FSCPX, a Chemical Widely Used as an Irreversible A鈧?Adenosine Receptor Antagonist, Modifies the Effect of NBTI, a Nucleoside Transport Inhibitor, by Reducing the Interstitial Adenosine Level in the Guinea Pig Atrium. Molecules. 2018 Aug 3 

[3]. Lee HT, et, al. Renal tubule necrosis and apoptosis modulation by A1 adenosine receptor expression. Kidney Int. 2007 Jun;71(12):1249-61.