Chondroitinase ABC (ChABC) is an enzyme that degrades glycosaminoglycan side-chains of chondroitin sulfate (CS-GAG) from the chondroitin sulfate proteoglycan (CSPG) core protein. Chondroitinase ABC facilitates reinnervation by degrading CS-GAGs around motoneurons. Chondroitinase ABC has the potential for the research of spinal injury.
[1]. Mahajan R, et al. Chondroitinase ABC Enzyme: A Potential Treatment Option for Spinal Cord Injury. Int J Appl Basic Med Res. 2018 Oct-Dec;8(4):203.
[2]. Takiguchi M, et al. Chondroitinase ABC Administration Facilitates Serotonergic Innervation of Motoneurons in Rats With Complete Spinal Cord Transection. Front Integr Neurosci. 2022 Jun 30;16:881632.
















