Albanol B is an arylbenzofuran derivative which can be isolated from mulberries. Albanol B exhibits anti-Alzheimer's disease, anti-bacterial and antioxidant activities. Albanol B inhibits cancer cells proliferation, down-regulates CDK1 expression. Albanol B also induces cell cycle arrest at G2/M and apoptosis. And Albanol B induces mitochondrial ROS production and increases the phosphorylation levels of AKT and ERK1/2.
Albanol B (10 渭M, 30 渭M; 24 h) decreases cell viability of A549 cells[1].
Albanol B (30 渭M; 48 h) arrrests cell cycle at G2/M phase and induces apoptosis in A549 and H1975 cells[1].
Albanol B (1-30 渭M; 1-9 h) mediates the activation of ERK-1/2 and AKT in A549 cells[1].
Albanol B (50 mg/kg, 100 mg/kg; ip; once daily for 21 days) inhibits tumor growth in Ex-3LL tumor bearing mice[1].
[1]. Phan TN, et al. Albanol B from Mulberries Exerts Anti-Cancer Effect through Mitochondria ROS Production in Lung Cancer Cells and Suppresses In Vivo Tumor Growth. Int J Mol Sci. 2020 Dec 14;21(24):9502.