Oxidized ATP (oATP) trisodium salt is a broad-spectrum P2 receptor inhibitor. Oxidized ATP trisodium salt irreversibly antagonizes P2X7R activation. Oxidized ATP trisodium salt inhibits c-reactive protein (CRP)-induced NLRP3 inflammasome activation. Oxidized ATP trisodium salt can be used for research of atherosclerosis.
Oxidized ATP trisodium salt (100 渭M, 1 h) inhibits CRP (20 渭g/mL, 24 h)-induced caspase-1 activation and maturation of IL-1尾 in HUVECs[1].
Oxidized ATP (300 渭g/mouse, i.p., twice a week) trisodium salt ameliorates the induced mouse experimental autoimmune uveitis (EAU) in B6 mice[2].
[1]. Bian F, et al. CRP-Induced NLRP3 Inflammasome Activation Increases LDL Transcytosis Across Endothelial Cells. Front Pharmacol. 2019 Jan 30;10:40.
[2]. Zhao R, et al. Blockade of Extracellular ATP Effect by Oxidized ATP Effectively Mitigated Induced Mouse Experimental Autoimmune Uveitis (EAU). PLoS One. 2016 May 19;11(5):e0155953.