Lunularin (Compound 3), a monoterpene, is a metabolite of gut microbiota-derivedResveratrol. Lunularin can be isolated from the liverwortConocephalum conicum. Lunularin is a selective11β-HSD1inhibitor withIC50s of 45.44 and 17.39 μM for human 11β-HSD1 and rat 11β-HSD1, respectively. Lunularin has significant anti-inflammatory and anti-cancer activities[1][2][3].
References:
[1].Suire C, et al. Chirality of terpenoids isolated from the liverwort Conocephalum Conicum[J]. Phytochemistry, 1982, 21(2): 349-352.
















