GLPBio

GIPR antagonist 1

Catalog No.: GC79203Purity:>98%
COASDSData Sheet
GIPR antagonist 1 is a GIPR antagonist with an IC50 of 4.8 nM.

Products are for research use only. Not for human use. We do not sell to patients.

GIPR antagonist 1
Cas No.: 3059497-30-9
1mgIn Stock
$143.00
1
5mgIn Stock
$356.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

No citations are currently available for this product. Below are selected publications citing GlpBio products.
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    Nature
    641, 529–536 (2025)
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    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
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    Science
    388(6745) (2025)
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    387(6739) (2025)
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    Science
    387(6734) (2025)
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    Cell Research
    35, 97–116 (2025)
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    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    Cell Research
    31, 1291–1307 (2021)

Description

GIPR antagonist 1 is a GIPR antagonist with an IC50 of 4.8 nM. GIPR antagonist 1 inhibits glucose-dependent insulinotropic polypeptide receptor signaling. GIPR antagonist 1 can be used for the research of type 2 diabetes and obesity [1].

In Vitro, GIPR antagonist 1 (Compound 27) (10-100 nM, 6 h) antagonizes human GIPR and inhibits downstream cAMP production in a concentration‑dependent manner in CHO‑K1 cells stably expressing human GIPR[1].

References:
[1]. Kevin James Filipski, et al. Glucose-dependent insulinotropic polypeptide receptor antagonists and uses thereof. WO2024214038A1. 2025-10-14

Chemical Properties

CAS No.
3059497-30-9
Molecular Formula
C28H29FN4O4
Molecular Weight
504.55
Storage
Store at -20°C
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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